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  1. Amyotrophic lateral sclerosis (ALS) - Symptoms and causes

    May 6, 2026 · Also known as ALS, the disease leads to muscle weakness and other symptoms that get worse over time. ALS often begins with muscle twitching and weakness in an arm or leg, trouble …

  2. ALS - Wikipedia

    ALS genes identified to date explain the cause of about 70% of familial ALS and about 15% of sporadic ALS. Overall, first-degree relatives of an individual with ALS have a ~1% risk of developing ALS …

  3. What is ALS? - Amyotrophic Lateral Sclerosis | The ALS Association

    ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. There is no cure for ALS yet.

  4. Early Signs of ALS You Shouldn't Ignore - Verywell Health

    Apr 1, 2026 · ALS makes your muscles weak over time, affecting your arms, legs, and the muscles you use to eat and breathe. Early signs of ALS include clumsiness, dropping things, and tripping due to …

  5. Amyotrophic Lateral Sclerosis (ALS) - National Institute of ...

    Mar 13, 2026 · Amyotrophic lateral sclerosis (ALS), formerly known as Lou Gehrig’s Disease, is a neurological disease that affects motor neurons—those nerve cells in the brain and spinal cord that …

  6. Amyotrophic Lateral Sclerosis (ALS) - Johns Hopkins Medicine

    Amyotrophic Lateral Sclerosis (ALS) What is ALS? Amyotrophic lateral sclerosis (ALS) is a fatal type of motor neuron disease. It causes progressive degeneration of nerve cells in the spinal cord and brain. …

  7. Very Early ALS Symptoms: What to Look Out For

    Oct 24, 2024 · ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder affecting motor neurons in the brain and spinal cord. As these nerve cells degenerate, they stop …

  8. Amyotrophic Lateral Sclerosis (ALS): What It Is & Symptoms

    May 6, 2025 · What is ALS? Amyotrophic lateral sclerosis, or ALS, is a neurodegenerative disease that targets the nerve cells (neurons) in your brain and spinal cord. It affects your muscle control. …

  9. New ALS therapy shows researchers "this illness can be stopped"

    May 8, 2026 · A new drug, called tofersen, can radically slow and even reverse the course of ALS.

  10. The mystery of why some people develop ALS - BBC

    Feb 20, 2026 · ALS is a form of motor-neurone disease (MND). It is a debilitating and painful condition in which the motor neurons – cells that control voluntary muscle movement – are gradually lost, leading …